3×3 Eyes Sanjiyan Henjyo (3×3 EYES 三只眼變成) is a game develop by Nihon Create and released on PC-9801, FM Towns, PC-Engine, Windows 3.1, and Windows 95.
Based on a manga, 3x3 Eyes (Japanese: サザンアイズ Hepburn: Sazan Aizu) follows the adventures of Pai, the last remaining Sanjiyan Unkara (三只眼 吽迦羅 lit. triclops), and her new Wu (Chinese reading of 无; an immortal companion), Yakumo, as they desperately try to find a way to make Pai human so that she can forget her troubled past. Pai travelled to Tokyo searching for the artifact, but shortly after she arrived, a thief snatched her backpack and cane from her. A teenage lad, Yakumo, tackled the crook and managed to get the pack back for her, though the thief escaped with the cane. Yakumo took her to his work, where Pai was able to get cleaned up, and where she discovered that he was the son of Professor Fujii, an archaeologist she had met in Tibet four years prior. The Professor had been researching the legends of the Sanjiyans and had befriended her and offered to help her find the Ningen, only to fall ill and die. Pai had his last letter to his son in her backpack, which asked Yakumo to help Pai with her quest. Although he didn't believe his father's tales of Pai being a monster, he agreed to assist her.